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Description
EGFL6 His Tag Protein, MouseProduct Specification Species Mouse Antigen EGFL6 Synonyms Egfl6, Maeg, MGC141463 Protein Accession Q9JJZ5 Amino Acid Sequence Thr287 Gly550, with C terminal 8*His TMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEGGGGSHHHHHHHH Expression
Product Specification
| Species | Mouse |
| Antigen | EGFL6 |
| Synonyms | Egfl6, Maeg, MGC141463 Protein |
| Accession | Q9JJZ5 |
| Amino Acid Sequence |
Thr287-Gly550, with C-terminal 8*His TMKKKVKLKMVTPRPASTRVPKVNLPYSSEEGVSRGRNYDGEQKKKEEGKRERLEEEKGEKTLRNEVEQERTLRGDVFSPKVNEAEDLDLVYVQRKELNSKLKHKDLNISVDCSFDLGVCDWKQDREDDFDWHPADRDNDVGYYMAVPALAGHKKNIGRLKLLLPNLTPQSNFCLLFDYRLAGDKVGKLRVFVKNSNNALAWEETKNEDGRWRTGKIQLYQGIDTTKSVIFEAERGKGKTGEIAVDGVLLVSGLCPDDFLSVEGGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 38-42kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. An, J., Du, Y., Fan, X. et al. EGFL6promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulatingtumor angiogenesis. Oncogene 38, 2123–2134 (2019).https://doi.org/10.1038/s41388-018-0565-9. |
Background
EGFL6, a member of the EGF-like superfamily, plays an important role during embryonic development and has been implicated in promotion of tumor angiogenesis without affecting wound healing. Importantly, expression of EGFL6 in cancer cells and tumor endothelial cells not only increased tumor angiogenesis but also promoted migration of cancer cells. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. EGFL6 gene is expressed early during development, and its expression has been detected in lung and meningioma tumors.
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