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Description
Napsin A Recombinant Mouse mAb (SDT-4204)Product Specification Host Mouse Antigen Napsin A Synonyms Napsin A; Aspartyl protease 4 (ASP4; Asp 4); Napsin 1; TA01 TA02; NAP1; NAPA; NAPSA Location Secreted Accession O96009 Clone Number SDT 4204 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein G Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability
Product Specification
| Host | Mouse |
| Antigen | Napsin A |
| Synonyms | Napsin-A; Aspartyl protease 4 (ASP4; Asp 4); Napsin-1; TA01/TA02; NAP1; NAPA; NAPSA |
| Location | Secreted |
| Accession | O96009 |
| Clone Number | SDT-4204 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein G |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
Napsin A is a 38-kDa, pepsin-fold aspartic protease encoded by chromosome 19q13 and expressed almost exclusively in type II pneumocytes and renal proximal tubular epithelial cells, where it participates in surfactant protein B maturation and endolysosomal protein catabolism; immunohistochemically its strong, granular cytoplasmic staining serves as a highly sensitive and specific marker for primary lung adenocarcinoma (positive in ~85 % of cases) while being consistently negative in squamous cell carcinoma, small-cell carcinoma, and most non-pulmonary adenocarcinomas except renal clear-cell carcinoma, making it a key component of modern diagnostic panels alongside TTF-1 for distinguishing pulmonary origin in metastatic settings.
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