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Description
Biotinylated Fc γ RIIIa/CD16a(F176) Avi&His Tag Protein, HumanProduct Specification Species Human Synonyms Fc RIIIa, CD16a, FcR 10 Accession P08637 1 Amino Acid Sequence Gly17 Gln208, with C terminal Avi & 8*His Tag GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQGGGSGLNDIFEAQKIEWHEHHHHHHHH Expression System HEK293 Molecular Weight 45 53kDa Purity >95% by SDS PAGE
Product Specification
| Species | Human |
| Synonyms | Fc γ RIIIa, CD16a, FcR-10 |
| Accession | P08637-1 |
| Amino Acid Sequence | Gly17-Gln208, with C-terminal Avi & 8*His Tag GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQGGGSGLNDIFEAQKIEWHEHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 45-53kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Nimmerjahn F. et al. (2006) Fcgamma receptors: old friends and new family members. Immunity J. 24(1): 19-28. |
Background
Fc gamma RIIIa is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. In humans, it is a 50-70 kDa type I transmembrane activating receptor expressed by NK cells, T cells, monocytes, and macrophages. A single nucleotide polymorphism creates high binding (V176) and low binding (F176) forms that, when homozygous, may influence susceptibility to autoimmune diseases or response to therapeutic IgG antibodies. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
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4.1 ★★★★★
Based on 121 reviews
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Product Reviews
★★★★★ 5
Our Yorkie Puppy Loves This Toy!!!
Color: Red
Warning: your pet may become completely obsessed
I’ve had this toy for about a year for my Yorkshire Terrier, Gia, and it’s easily the most successful toy purchase I’ve ever made. We even had to replace the first one after she loved it a little too much (chewed the string off), and have since bought more as gifts for friends’ pets. Great toy for small dogs (too fragile for bigger dogs) and active, young cats.)
What we love:
* Endless engagement: Gia ignores all her other toys and goes straight for this every time
* Interactive features: Subtle beeping + changing colored lights + unpredictable rolling patterns keep her hooked
* Energy burner: Perfect for indoor play on hardwood floors—she will chase it nonstop
* Rechargeable: Battery lasts several hours, even with frequent use
* Durability: Holds up well considering how rough she plays
Real-life note:
Gia will literally bring this toy to me to get me involved—and I have to limit her playtime because she won’t stop on her own.
Bottom line:
If you have a high-energy dog (or even a playful cat), this isn’t just a toy—it becomes their favorite activity… and possibly their entire personality.
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Reviewed in the United States on April 25, 2026
★★★★★ 3
I wanted it to be a good fit
Color: Red
This toy garnered my dogs attention for a day. We tried it inside but there's too many places it would go under. We tried ot outside and it was powerful enough in the grass so tried concrete patio. My dog lost interest sadly. It wasn't a good product for my dog.
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Reviewed in the United States on June 5, 2026
★★★★★ 5
My pup loved it.
Color: Red
“Bought this for my dog Loki and it was an instant hit. He usually loses interest in toys pretty quickly, but this ball kept him entertained way longer than expected. The lights and movement immediately grabbed his attention, and he spent a solid hour chasing, pawing, and carrying it around the house.
It’s durable enough for excited play, easy to charge/use, and even survived Loki’s dramatic ‘victory laps’ through the living room. Bonus: it tired him out enough for an actual nap afterward. Definitely worth it for high-energy dogs or curious pets.”
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Reviewed in the United States on May 14, 2026
★★★★★ 5
Great toy to occupy pet
Color: Red, Color: Red
This ball is super fast, and lasts very long on one charge. It really keeps my cat entertained, he’s just so curious about it. It’s easy to pick out dust any hair it might catch on, it’s rubber material is durable. It’s a stable toy since my cat likes to play roughly.
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Reviewed in the United States on May 16, 2026
★★★★★ 5
Great for Puppies!
Color: Red
This toy has been a great purchase for my new puppy! He has so much fun playing with it and stays engaged for long periods. While it can move a little fast at first, the adjustable speed settings make it easy to customize. Overall, it’s a fantastic toy that keeps him active, entertained, and happy.
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Reviewed in the United States on June 12, 2026