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- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 8 - Jul 13
For Your Every Summer RSVP, with Code: SUMMER15
Description
MUC4 Recombinant Rabbit mAb,PBS Only (SDT-R228)Product Specification Host Rabbit Antigen MUC4 Synonyms Ascites sialoglycoprotein (ASGP), Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin4, MUC 4 Location Secreted, Cell membrane Accession Q99102 Clone Number SDT R228 Antibody Type Recombinant mAb Application IHC P Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | MUC4 |
| Synonyms | Ascites sialoglycoprotein (ASGP), Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin4, MUC-4 |
| Location | Secreted, Cell membrane |
| Accession | Q99102 |
| Clone Number | SDT-R228 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 |
Background
Mucin 4 (MUC4) is a highly glycosylated type I transmembrane glycoprotein. Normally acts as barrier to apical surface of epithelial cells, playing a protective and regulatory role. MUC4 expression is erroneous in many carcinomas and sarcomas, including sclerosing epithelioid fibrosarcoma and pancreatic adenocarcinoma. Immunohistochemical staining for MUC4 has been discussed as a potential biomarker for detection of these cancers. MUC4 can serve as a ligand for the oncogenic receptor ErbB2 and a modulator of its phosphorylation and signaling. MUC4 is frequently aberrantly expressed in epithelial tumors and can promote tumor growth and metastasis.
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