PE Mouse Anti-Human CD110 Antibody (S-3014)
SKU: 55807805054

PE Mouse Anti-Human CD110 Antibody (S-3014)

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Description

PE Mouse Anti-Human CD110 Antibody (S-3014)Product Specification Host Mouse Antigen CD110 Synonyms Thrombopoietin receptor; TPO R; Myeloproliferative leukemia protein; Proto oncogene c Mpl; TPOR; MPL Location Cell membrane Accession P40238 Clone Number S 3014 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample human peripheral blood cells Purification Protein A Concentration 0. 2 mg ml Conjugation PE Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%

Product Specification


Host Mouse
Antigen CD110
Synonyms Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; TPOR; MPL
Location Cell membrane
Accession P40238
Clone Number S-3014
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood cells
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD110, also known as thrombopoietin receptor (TPOR) or MPL (myeloproliferative leukemia protein), is a 635-amino-acid, single-pass type I transmembrane glycoprotein belonging to the hematopoietic cytokine receptor superfamily, whose extracellular N-terminal region binds thrombopoietin (TPO) with high affinity to activate JAK2/STAT, MAPK and PI3K-AKT signaling cascades that drive megakaryocyte proliferation, differentiation and platelet production, while its cytoplasmic C-terminal tail contains critical motifs for internalization and negative feedback regulation; physiologically expressed on hematopoietic stem cells, megakaryocytes, platelets and endothelial cells, CD110 is essential for steady-state and stress hematopoiesis, and genetic alterations—such as MPL W515L/K activating mutations or CALR exon 9 mutations that create neomorphic ligand binding—lead to ligand-independent signaling, constitutive activation and the development of myeloproliferative neoplasms, making CD110 a key diagnostic marker and therapeutic target for small-molecule JAK inhibitors and TPO receptor agonists/antagonists in thrombocytopenias and myelofibrosis.

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SKU: 55807805054

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JL
Draper, US
★★★★★ 5
Nice shirt at a good price
Size: Small, Color: Indigo
Nice shirt, fits well and is a nice color and button layout. It was a good deal.
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Reviewed in the United States on April 7, 2026
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Mark benn
Chelsea, US
★★★★★ 5
Love it
Size: Large, Color: Indigo
Good quality
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Reviewed in the United States on May 20, 2026
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Jon J. Sanders
Cuba, US
★★★★★ 3
Its OK but wrinkles easily.
Size: X-Large, Color: Light Khaki Brown
Decent shirt and fits well, but wrinkle city! I could barely iron them out after washing.
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Reviewed in the United States on May 25, 2026
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Jacob
New York, US
★★★★★ 5
Good shirt.
Size: Large Tall, Color: Green Camo Print
New favorite shirt. Definitely a LT. cheapest big and tall button down i could find and i love it.
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Reviewed in the United States on April 10, 2026
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Dan
Draper, US
★★★★★ 4
Nice shirt but size up one to two sizes.
Size: Large, Color: Clay
I love this shirt. it is good quality. I got the clay colored one. I really like it. They do run small. I normally wear a medium. So I got a large. It fits pretty well. It is a tad bit tight, but I am losing weight(145LBS) So far. So it should fit fine in a few weeks. I am 5,2 135Lbs. I probably should have gotten the XL.
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Reviewed in the United States on May 17, 2026

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