Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
TrkC Fc Chimera Protein, HumanProduct Specification Species Human Synonyms TrkC, Ntrk3 Accession Q96CY4 Amino Acid Sequence Cys32 Asp428, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | TrkC, Ntrk3 |
| Accession | Q96CY4 |
| Amino Acid Sequence | Cys32-Asp428, with C-terminal Human IgG1 Fc CPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 95-115kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Khotskaya Y B. et al. (2017). Targeting TRK family proteins in cancer. Review. 173:58-66. |
Background
The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of neurotrophins to TRK proteins induces receptor dimerization, phosphorylation, and activation of the downstream signaling cascades via PI3K, RAS/MAPK/ERK, and PLC-gamma. TrkC functions not only as an oncogene, but also act as a tumor suppressor via a manner of dependence receptor in human malignant tumors. TrkC is a potent oncoprotein expressed in tumors derived from multiple cell lineages, and functions as an active protein tyrosine kinase by neurotrophin-3 (NT-3).
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.6 ★★★★★
Based on 2149 reviews
Sort
Product Reviews
★★★★★ 3
They stand out, and are flashy, but sizing is complicated.
Size: 34, Color: Black With White Strip, Size: 34, Color: Black With White Strip
High-quality pants and flashy. The stripe adds a lot of attention for reasons both good and bad.
The materials they were made are excellent quality. Pants are thick, but not too thick, and are lightweight, guaranteeing easy movement. Comfortable - could wear these all day.
I do love their appearance. They made me feel like a million bucks. :)
The only problem is sizing and fit. I normally wear size 34 for waist in jeans and dress pants like these, but the 34 I got didn't fit at all - too tight. So, I ordered a 36, and it fit, but barely. When I sat down, there was too much tightness in my "masculine area". I also ordered a 38, and, well, they were just too big - practically hung off me.
A 37 would probably work for me in these, but they don't offer such a size. I have to return the 34 and 38. Will keep the 36, see if I can have it altered in some way.
Length was fine. Being 1.86 meters, often the length in these pants is a little on the short side.
In the photo, I'm wearing size 36 and the black pair with the gold stripe, which is actually more of a flashy yellow. I liked how I looked in them, but they were a little too tight at times, the belt wasn't even necessary. It enhanced the outfit though, don't you think.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 20, 2025
★★★★★ 5
Good as a standard "Tuxedo" pants
Size: 42, Color: Black With Red Strip
Red Striping could be wider. These are good as a standard "Tuxedo" pants but if you are looking more fore a "Security Guard" style pants the striping needs to be wider.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 18, 2025
★★★★★ 5
Runs small in the waist
Size: 34, Color: Black With Black Strip
These are good pants, but as other reviewers have noted, they tend to run small. Order one size up from the size you normally order. I'm a 34 inch waist, and I ordered the 34. They were tight, and I had to have them let out. I may order another pair, and if so, I'll order the 36.
Don't be vain. Be smart.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 6, 2015
★★★★★ 1
Poor fit
Size: 42, Color: Black With Golden Yellow
Poor fit and drape is consistent with the low price
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 2, 2025
★★★★★ 5
Good value
Size: 40, Color: Black With Black Strip
My husband and brother in law both found these pants to fit a little smaller than regular dress pants.....mostly they were tighter in the thighs but the length/waist was perfect. They each ordered a size or two up and had the pants tailors to fit. They looked very sharp and were of a good quality considering they were not super expensive. I hope they have the chance to wear these more often!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 6, 2013