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Description
p40 Recombinant Rabbit mAb,PBS Only (SDT-166-116)Product Specification Host Rabbit Antigen p40 Synonyms Tumor protein 63; p63; Chronic ulcerative stomatitis protein (CUSP); Keratinocyte transcription factor KET; Transformation related protein 63 (TP63); Tumor protein p73 like (p73L); p51 Immunogen Synthetic Peptide Location Nucleus Accession Q9H3D4 4 Clone Number SDT 166 116 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Purification Protein A Concentration 1 mg ml
Product Specification
| Host | Rabbit |
| Antigen | p40 |
| Synonyms | Tumor protein 63; p63; Chronic ulcerative stomatitis protein (CUSP); Keratinocyte transcription factor KET; Transformation-related protein 63 (TP63); Tumor protein p73-like (p73L); p51 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q9H3D4-4 |
| Clone Number | SDT-166-116 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:200 | Hu |
Background
p63 (TAp63) is closely related to p40 (ΔNp63) as both proteins represent isoforms of the p63 gene with distinct molecular functions. While “full length” p63 (TAp63) activates p53 target genes such as p21 or BAX, the shorter transcript p40 (ΔNp63) inhibits activation of p53 and “full length” p63. Among carcinomas, p40 has approximately the same sensitivity as p63 but a higher specificity, as the TAp63 isoform is expressed more widespread in eg., adenocarcinomas. Moreover, p63 occur in lymphomas that are p40 negative.
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