Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
CRBN GST&His Tag Protein, HumanProduct Specification Species Human Synonyms CRBN, AD 006, MRT2, MRT2A Accession Q96SW2 Amino Acid Sequence Met1 Leu442, with N terminal GST
Product Specification
| Species | Human |
| Synonyms | CRBN, AD-006, MRT2, MRT2A |
| Accession | Q96SW2 |
| Amino Acid Sequence |
Met1-Leu442, with N-terminal GST MSGSHHHHHHSSGMSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLGHTGHRSGDDDDKMAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL |
| Expression System | E.coli |
| Molecular Weight | 76-78kDa (Reducing) |
| Purity | >90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag, GST Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Stability & Storage | · 12 months from date of receipt, -20 to -70 °C as supplied. |
| Reference |
|
Background
Cereblon (CRBN; a member of the ATP-dependent Lon protease) is an enzyme implicated in memory and learning. Interestingly, CRBN and KCa1.1 are both highly expressed in the same areas of the brain, including the hippocampus, which is known for its involvement in memory and learning. These two proteins bind directly to each other via the C-terminus of KCa1.1 in vitro, and their proximity in brain has been confirmed biochemically and by visualization of immunolabeled complexes in cultured hippocampal neurons. Ectopically expressed CRBN suppresses KCa1.1 surface expression by disrupting the formation of tetramers and therefore functional channels. The physiological consequences of the interaction between CRBN and KCa1.1 remain to be explored, although inherited mutations of the human cereblon gene (CRBN) or KCa1.1 lead to mental retardation disorders. And substrate recognition component of a DCX (DDB1-CUL4-X- Box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Regular degradation of Key regulatory proteins is necessary for Normal limb outgrowth and expression of the fibroblast growth factor FGF8.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy