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Ships within 48 hours · Estimated delivery Jul 8 - Jul 13
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For Your Every Summer RSVP, with Code: SUMMER15
Description
GFRAL Fc Chimera Protein, HumanProduct Specification Species Human Synonyms GFR alpha like,GRAL,GDNF family receptor alpha like Accession Q6UXV0 Amino Acid Sequence Ser19 Glu351 with Human IgG1 Fc at the C Terminus Expression System HEK293 Molecular Weight 60 80kDa (Reducing) Purity 95% by SDS PAGE &SEC HPLC Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Human |
| Synonyms | GFR alpha like,GRAL,GDNF family receptor alpha-like |
| Accession | Q6UXV0 |
| Amino Acid Sequence | Ser19-Glu351 with Human IgG1 Fc at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 60-80kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE &SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Airaksinen MS, Holm L, Hätinen T. Evolution of the GDNF family ligands and receptors. Brain Behav Evol. 2006;68(3):181-90. |
Background
GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) is a divergent transforming growth factor (TGFbeta) superfamily cytokine implicated in biological and disease processes including metabolism, cancer, and chronic inflammation. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
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