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Description
p38 delta/MAPK13 + p38 alpha/MAPK14 Recombinant Mouse mAb (S-3860)Product Specification Host Mouse Antigen p38 delta MAPK13 + p38 alpha MAPK14 Synonyms Mitogen activated protein kinase; MAP kinase; MAPK Location Cytoplasm, Nucleus Accession Q16539O15264 Clone Number S 3860 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, A431, NIH 3T3 Predicted Reactivity BV, Dg, Hm, AfGrMk Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Mouse |
| Antigen | p38 delta/MAPK13 + p38 alpha/MAPK14 |
| Synonyms | Mitogen-activated protein kinase; MAP kinase; MAPK |
| Location | Cytoplasm, Nucleus |
| Accession | Q16539、O15264 |
| Clone Number | S-3860 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, Jurkat, A431, NIH/3T3 |
| Predicted Reactivity | BV, Dg, Hm, AfGrMk |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
MAPK13 and MAPK14, commonly known as p38δ and p38α respectively, are critical members of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Functioning as essential intracellular signaling molecules, they are primarily activated in response to diverse stress stimuli, such as inflammatory cytokines, environmental stress, and oxidative stress. Their activation depends on the dual phosphorylation of specific threonine and tyrosine residues, which in turn regulates the activity of numerous downstream transcription factors and proteins. MAPK14 (p38α) is the most extensively studied and ubiquitously expressed isoform, playing a central role in processes like inflammatory responses, apoptosis, cell differentiation, and cell cycle regulation, making it a significant drug target for inflammatory and autoimmune diseases. In contrast, MAPK13 (p38δ) exhibits a more tissue-specific expression pattern, predominantly found in glandular tissues (e.g., salivary glands, pancreas), skin, and lungs, where it fulfills distinct roles in tissue-specific inflammation, skin pathophysiology, and the regulation of insulin secretion. Although they share upstream activators and some downstream substrates, MAPK13 and MAPK14 exhibit both overlapping and complementary physiological functions, collectively forming a core network for the precise cellular regulation of stress responses.
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