p38 delta/MAPK13 + p38 alpha/MAPK14 Recombinant Mouse mAb (S-3860)
SKU: 88791772366

p38 delta/MAPK13 + p38 alpha/MAPK14 Recombinant Mouse mAb (S-3860)

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Description

p38 delta/MAPK13 + p38 alpha/MAPK14 Recombinant Mouse mAb (S-3860)Product Specification Host Mouse Antigen p38 delta MAPK13 + p38 alpha MAPK14 Synonyms Mitogen activated protein kinase; MAP kinase; MAPK Location Cytoplasm, Nucleus Accession Q16539O15264 Clone Number S 3860 Antibody Type Mouse mAb Isotype IgG1,k Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, Jurkat, A431, NIH 3T3 Predicted Reactivity BV, Dg, Hm, AfGrMk Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical

Product Specification


Host Mouse
Antigen p38 delta/MAPK13 + p38 alpha/MAPK14
Synonyms Mitogen-activated protein kinase; MAP kinase; MAPK
Location Cytoplasm, Nucleus
Accession Q16539、O15264
Clone Number S-3860
Antibody Type Mouse mAb
Isotype IgG1,k
Application WB, IHC-P
Reactivity Hu, Ms, Rt
Positive Sample HeLa, Jurkat, A431, NIH/3T3
Predicted Reactivity BV, Dg, Hm, AfGrMk
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms
IHC-P 1:1000 Hu, Ms, Rt

Background

MAPK13 and MAPK14, commonly known as p38δ and p38α respectively, are critical members of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. Functioning as essential intracellular signaling molecules, they are primarily activated in response to diverse stress stimuli, such as inflammatory cytokines, environmental stress, and oxidative stress. Their activation depends on the dual phosphorylation of specific threonine and tyrosine residues, which in turn regulates the activity of numerous downstream transcription factors and proteins. MAPK14 (p38α) is the most extensively studied and ubiquitously expressed isoform, playing a central role in processes like inflammatory responses, apoptosis, cell differentiation, and cell cycle regulation, making it a significant drug target for inflammatory and autoimmune diseases. In contrast, MAPK13 (p38δ) exhibits a more tissue-specific expression pattern, predominantly found in glandular tissues (e.g., salivary glands, pancreas), skin, and lungs, where it fulfills distinct roles in tissue-specific inflammation, skin pathophysiology, and the regulation of insulin secretion. Although they share upstream activators and some downstream substrates, MAPK13 and MAPK14 exhibit both overlapping and complementary physiological functions, collectively forming a core network for the precise cellular regulation of stress responses.

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SKU: 88791772366

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4.2 ★★★★★
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F. Collins
West Palm Beach, US
★★★★★ 5
Kubrick’s revelatory swan song is full of hidden meanings
An underrated masterpiece, Eyes Wide Shut is a gem layered with meaning. A semi-autobiographical sensibility permeates given the parameters of its production. It’s immaculately shot, edited and designed and offers two central performances from the then married Tom Cruise and Nicole Kidman. Given its theme, their subsequent divorce reflects back on the choppy waters faced by their characters Bill and Alice Harford. The result is a dream logic of coincidences that ensnare a married couple in self doubt and sexual angst. They live a fairly privileged life in a Manhattan apartment but after a Christmas party at a huge mansion owned by an elite acquaintance, the relationship begins to unravel when both are confronted by the consequences of their projected desires. This prompts the husband Bill on an odyssey through a night time New York and an escalating series of encounters as his wife’s confession about an infatuation with another man eats away at his own inner, unfulfilled desires. It’s a dark/light solstice of a film, as man and wife chase fatalistic hidden desire, their marriage subject to dissolution and they plunge through a dark night of the soul and emerge into a morning of earnest confession and much soul searching. In the end, it’s a fascinating watch. Quite revelatory given my initial reception to it many decades ago. But that’s Kubrick for you. It’s essential to revisit his films. Beautifully presented in 4K by Criterion, it asks us to take ownership of our inner desires, to confront them with honesty and discern what is merely a dream from the reality around us. And no, it’s not the erotic thriller the marketing promised. Another desire thwarted or a deliberate obfuscation of the intense psychological drama it really was?
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 26, 2026
S
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Steve
Lexington, US
★★★★★ 5
Everything Has Already Been Said
SK’s Final Masterpiece. Truly, it’s outstanding, as all of his films are. About the transfer. This is what they had to work with. For some reason, 2001, ACO, TS, and FMJ all look 4K, so to speak. This one looks a little grainy. I can’t complain. It’s better than nothing.
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Reviewed in the United States on March 17, 2026
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Neil Traugh, Jr.
Port Orchard, US
★★★★★ 5
Opinion on EWS
When I upgraded from Blu-ray to 4K Blu-ray, always wonder whether the transfer was good. This one was done well and you should like it. I watch on an OLED 83” FYI for comparison.
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Reviewed in the United States on April 15, 2026
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Lex
Los Angeles, US
★★★★★ 5
Excellent Remastering on 4k.. hits harder today considering the Epstein scandal
Curious about the Epstein Class... Kubrick pulls back the curtain with this one.
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Reviewed in the United States on May 10, 2026
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G P
Lexington, US
★★★★★ 5
it's kubrick. it's a masterpiece.
i don't really like movies about couples but being kubrick, i gave it a chance. the cinematography is just so incredibly rich, not only with flashy scenes and beautiful colors and framing, but with all these referential easter eggs and nuggets of hints and symbolism and...oh my god it's just RICH. if you like psychological and mystery stuff, and photography, and lurid secret society stuff, this movie is incredible. i will watch it again for sure.
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Reviewed in the United States on January 21, 2026

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