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Description
MIS RII mFc Chimera Protein, HumanProduct Specification Species Human Synonyms MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor Accession Q16671 1 Amino Acid Sequence Pro18 Ser144 with Mouse IgG2a Fc Tag at the C Terminus Expression System HEK293 Molecular Weight 48 60kDa (Reducing) Purity 90% by SDS PAGE Conjugation Unconjugated Tag Mouse IgG2a Fc Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to
Product Specification
| Species | Human |
| Synonyms | MIS RII,MRII,AMHR2,AMHR,MISR2,AMH type II receptor |
| Accession | Q16671-1 |
| Amino Acid Sequence | Pro18-Ser144 with Mouse IgG2a Fc Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 48-60kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | Mouse IgG2a Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Zhao J, Feng B, Zheng MH, Xu K. Surgical robots for SPL and NOTES: a review. Minim Invasive Ther Allied Technol. 2015 Feb;24(1):8-17. |
Background
MIS RII (Mullerian inhibiting substance type II receptor), also known as AMHRII (anti-Mullerian hormone type II receptor), is a serine/threonine receptor with a single transmembrane domain that belongs to the family of type II receptors of the TGF-beta superfamily. Mutations in MIS RII result in persistent Mullerian duct syndrome (PMDS), persistent Müllerian duct syndrome (PMDS) is a sex-limited disorder in which males develop portions of the female reproductive tract. Anti-Müllerian hormone (AMH) and its receptor (AMHR2) induce the regression of the Müllerian ducts in male embryos, but the mechanism by which the Amhr2 gene is specifically activated is not fully understood.
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