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Description
RNF43 mFc Chimera Protein, MouseProduct Specification Species Mouse Synonyms RNF43, RING finger protein 43 Accession Q5NCP0 Amino Acid Sequence Ala34 Tyr197, with C terminal mIgG2a Fc Expression System HEK293 Molecular Weight 55 60kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Mouse Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | RNF43, RING finger protein 43 |
| Accession | Q5NCP0 |
| Amino Acid Sequence | Ala34-Tyr197, with C-terminal mIgG2a Fc |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Mouse Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Radaszkiewicz T. et al. (2021) RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion. eLife Sciences. 10. |
Background
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A- induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the core receptor complex components dedicated to the noncanonical Wnt pathway such as ROR1, ROR2, VANGL1, and VANGL2. RNF43 triggers VANGL2 ubiquitination and proteasomal degradation and clathrin- dependent internalization of ROR1 receptor and inhibits ROR2 activation. These activities of RNF43 are physiologically relevant and block pro-metastatic WNT5A signaling in melanoma. RNF43 inhibits responses to WNT5A, which results in the suppression of invasive properties of melanoma cells.
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4.3 ★★★★★
Based on 674 reviews
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Product Reviews
★★★★★ 4
So cute
Size: Large, Color: Pumpkin
My French Bulldogs have really strong jaws and are aggressive chewers. These really are sturdy and last a good amount of time. They are a bit heavy and awkward for my dogs to hold onto but they do like them.
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Reviewed in the United States on April 25, 2026
★★★★★ 5
Cute toy and super tough!
Size: Small, Color: Lobster
My small dog is a serious chewer, and this lobster toy has been holding up great. Usually, he destroys toys within a day, but this one’s still going strong after a couple of weeks. The shape is perfect — easy for him to grab and chew, and the little claws keep him entertained.
The filet mignon flavor must be good because he goes right for it every time. It’s sturdy without being too hard on his teeth, and it doesn’t leave any mess or pieces behind.
If you’ve got a small but mighty chewer, this one’s definitely worth it. Cute design, lasts forever, and keeps my pup busy — total win. 🦞🐾
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Reviewed in the United States on October 26, 2025
★★★★★ 5
Excellent toy
Size: X-Large, Color: Lobster
Very durable. Dog who has destroyed every toy ever purchased loves this and it is still in great condition.
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Reviewed in the United States on April 21, 2026
★★★★★ 3
Cheese the Day with Nylabone's Power Chew Cheese Chew Toy!
Size: X-Large, Color: Cheese
As a devoted dog parent, I've always believed that our furry friends deserve the best, especially when it comes to their favorite pastime—chewing! Nylabone's Power Chew Cheese Chew Toy is a game-changer that's added an extra layer of excitement to our dog's chewing routine.
**Chew-Tastic Design:**
First things first, the cheese-inspired shape of this chew toy is a hit in our household. Our dog can't resist its quirky design, and it's become a beloved addition to his chew toy collection. It's like a fun surprise every time he reaches for it!
**Flavor Pockets for Fun:**
What truly sets this chew toy apart is its flavor pockets. We fill them with spreadable treats, turning regular chew time into an epic adventure. Our dog absolutely loves the challenge of getting every last bit of treat, and it keeps him engaged for hours.
**Dental Health Bonus:**
Beyond the fun factor, the unique textures on this toy serve a dual purpose. Not only do they provide extra sensory enjoyment for our pup, but they also help clean his teeth as he chews. It's a win-win for both entertainment and dental health.
**Built to Last:**
Now, let's talk durability. Our dog is a power chewer, and this toy has proven to be up to the challenge. Made from Nylabone's most robust material, it's stood the test of time, promoting healthy chewing habits and saving our furniture from destruction.
**Satisfaction All Around:**
This chew toy isn't just for our dog's enjoyment; it brings joy to our family too. Seeing our furry friend so engaged and happy is priceless. It satisfies his natural urge to chew while teaching him healthy chewing habits.
**A Flavorful Experience:**
Did I mention the cheese flavor? It runs throughout the toy, adding another layer of enjoyment for our pup. It's like a delicious treat that never ends!
**Perfect for Big Dogs:**
As the proud parent of an extra-large dog, we opted for the "Souper" size, designed for dogs over 50 pounds. It's the perfect size for our gentle giant.
In conclusion, Nylabone's Power Chew Cheese Chew Toy has become an integral part of our dog's life. It's more than just a chew toy; it's an adventure, a dental health solution, and hours of entertainment all rolled into one. We've embraced the mantra of "Cheese the Day" with this fantastic chew toy, and we wholeheartedly recommend it to fellow dog parents looking to add more joy and flair to their furry friend's life!
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Reviewed in the United States on October 27, 2023
★★★★★ 5
Dog approved.
Size: X-Large, Color: Cheese
I’m a 70 lbs Goldendoodle (supposed to be 65, don’t ask) and I love cheese. Real cheese. Sharp cheddar with sourdough bread is my dream, but apparently I’m “on a health journey,” so my people bought me this instead.
Does this bone actually taste like cheese? No. I am not fooled.
Do I still enjoy chewing it loudly while my humans are trying to watch TV? Absolutely yes.
This bone satisfies my need to chew and my emotional desire for cheese-adjacent activities. It keeps me busy, saves the furniture, and lets me crunch dramatically during important dialogue scenes. The yellow color is nice — very cheese-coded — although some cheeses are white, so just something to consider for future versions.
Also, good news: it doesn’t smell like cheese at all, which my humans seem very grateful for. Apparently they don’t want the carpet to smell like a deli. Weird.
Final verdict:
Not cheese.
Still enjoyable.
Would chew again.
~Barley
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Reviewed in the United States on February 4, 2026