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Description
MMP-9(20-707) His Tag Protein, HumanProduct Specification Species Human Synonyms CLG4B, GELB, MANDP2, Gelatinase B, Matrix metalloproteinase 9 Accession P14780 Amino Acid Sequence Ala20 Asp707 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 80 100kDa (Reducing) Purity 95% by SDS PAGE & > 95% SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml
Product Specification
| Species | Human |
| Synonyms | CLG4B, GELB, MANDP2, Gelatinase B, Matrix metalloproteinase-9 |
| Accession | P14780 |
| Amino Acid Sequence | Ala20-Asp707 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 80-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 95% SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Zhang X, Liu Z, Li Y, He J, Yang L, Yan Y, Tong S, Wang Y, Zhang T. Lead acetate (PbAc) impairs blood-brain barrier in zebrafish via MMP-9/13-induced pericyte developmental defects. Ecotoxicol Environ Saf. 2025 Oct 24;305:119250. |
Background
Matrix metalloproteinase-9 (MMP-9, also known as 92 kDa gelatinase B) is a structurally complex key protease capable of degrading extracellular matrix components such as type IV collagen and gelatin. Secreted by various cells including neutrophils and macrophages, it plays vital roles in both normal tissue remodeling and pathological inflammatory processes. The activity of this enzyme requires precise regulation, and its overexpression can disrupt tissue homeostasis, thereby actively contributing to the pathogenesis of various diseases such as rheumatoid arthritis, multiple sclerosis, and tumor invasion. Consequently, it is regarded as a highly potential and important therapeutic target.
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