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Description
Mouse Anti-Human PU.1 Antibody (S-4307)Product Specification Host Mouse Antigen PU. 1 Synonyms Transcription factor PU. 1; SPI1 Location Nucleus Accession P17947 Clone Number S 4307 Antibody Type Mouse mAb Isotype IgG2a Application ICFCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied
Product Specification
| Host | Mouse |
| Antigen | PU.1 |
| Synonyms | Transcription factor PU.1; SPI1 |
| Location | Nucleus |
| Accession | P17947 |
| Clone Number | S-4307 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:2000 | Hu |
Background
PU.1, also known as SPI1 (Spleen Focus Forming Virus Proviral Integration Oncogene), is a critical ETS-family transcription factor that serves as a master regulator of hematopoiesis, specifically governing the development, differentiation, and functional maturation of myeloid lineages (including monocytes, macrophages, and granulocytes) and B lymphocytes. Functioning by binding to specific purine-rich DNA sequences via its highly conserved ETS domain, PU.1 orchestrates complex gene regulatory networks by recruiting co-activators or co-repressors to control the expression of hundreds of target genes essential for immune cell identity, such as those encoding cytokine receptors, signaling molecules, and lineage-specific enzymes; its activity is tightly dosage-dependent, where precise expression levels determine cell fate decisions, with high levels promoting macrophage differentiation and lower levels favoring B-cell development, while its dysregulation, mutation, or aberrant overexpression is strongly implicated in various hematological malignancies, particularly acute myeloid leukemia (AML) and certain types of lymphoma, making it a pivotal molecule for understanding both normal immune system architecture and leukemogenesis.
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