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Description
VCAM-1/CD106 His Tag Protein, MouseProduct Specification Species Mouse Synonyms VCAM1,CD106,INCAM 100,vascular cell adhesion molecule 1,vascular cell adhesion protein 1,V CAM 1 Accession P29533 1 Amino Acid Sequence Phe25 Glu698 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 90 100kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution
Product Specification
| Species | Mouse |
| Synonyms | VCAM1,CD106,INCAM-100,vascular cell adhesion molecule 1,vascular cell adhesion protein 1,V-CAM 1 |
| Accession | P29533-1 |
| Amino Acid Sequence | Phe25-Glu698 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-100kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Xia Z, Jiang L, Cai X, Jing J, Li S, Wang M, Wang S, Wang X, Wei T, Wang Y, Pan Y, Wang Y. Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population. Int J Stroke. 2025 Sep 5:17474930251380170. |
Background
Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 expression is induced by IL-1 beta, IL-4, TNF-alpha and IFN-gamma. VCAM-1 binds to leukocyte integrins VLA-4 and alpha 4 beta 7. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. During the inflammatory adhesion mechanism, activated integrins halt rolling leukocytes and attach them firmly to the vascular endothelium. They do this by binding to their ligands, for example VCAM-1, on endothelium. The VCAM-1: VLA-4/ alpha 4 beta 7 interaction is also thought to be involved in the extravasation of white blood cells through the blood vessel wall to sites of inflammation. ELISA techniques have shown that detectable levels of soluble VCAM-1 are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of VCAM-1 may be elevated or lowered in subjects with a variety of pathological conditions.
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