CD40/TNFRSF5 His Tag Protein, Cynomolgus
SKU: 98976281071

CD40/TNFRSF5 His Tag Protein, Cynomolgus

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Description

CD40/TNFRSF5 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with C terminal His Expression System HEK293 Molecular Weight 26 33kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence Glu21-Arg193, with C-terminal His
Expression System HEK293
Molecular Weight

26-33kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

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SKU: 98976281071

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bstu
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★★★★★ 5
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So I’ve used wood over the years to level out my Class A RV’s and even with the wood sealed, there is always one side that takes a beating. I figured I would try these Camco rectangular leveling blocks and was very surprised at their strength. I’ve only used them twice, but both times the RV rolled right up with no issues. The RV sitting on those blocks in the picture is a 40’ Tiffin diesel pusher. My only issue is the dual wheel base for this big RV, is too wide to use the blocks perpendicular to the wheels, so I had to use 3 blocks parallel (see pics) for each wheel, which required me to purchase two sets. Most sites I setup up at fairly level, but this just provides that little extra height if needed.
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Reviewed in the United States on April 20, 2026
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dwayne rogers
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★★★★★ 5
compact and sturdy
Size: 8.5" x 8.5", Color: Yellow
works great
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Reviewed in the United States on April 23, 2026
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Richard Allen
Natrona Heights, US
★★★★★ 5
Simple and easy to use
Color: Yellow, Size: 5.5" Lift
We took a late fall trip to Branson Missouri pulling our Camper. We had to use the Camco Trailer Aid when we got to our campsite and it performed as advertised. Good sturdy product that worked as advertised.
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Reviewed in the United States on December 30, 2025
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Thomas Schleis
Bozeman, US
★★★★★ 5
A Must-have for Double-axle Travel Trailers
Color: Yellow, Size: 5.5" Lift
I moved from a diesel pusher motorhome back to a truck and Lance travel trailer. ‘Done with Diesels’ is my new motto. I wanted to check the wheel bearings and couldn’t find the proper way to jack up the side. Some people said jack here, some said jack there, and some said never to use a jack at all, so I was confused. Decided to use some of my leveling blocks and build a ramp to drive up onto and that ended in failure. Either it wouldn’t go up without spitting it out and still wasn’t high enough. I resorted to jacking it up at the spot I thought was best, but wasn’t comfortable with the entire side supported with a small bottle jack cylinder. So I ordered this and it was well worth the wait. Trailer pulls right up onto it and the other tire is ready to work on. The weight is more evenly distributed and certainly feels safer. Obviously this won’t work for a single axle, but for double axles it works for maintenance and makes tire changing a breeze. It’s as good as everyone says it is and has a permanent place in my trailer storage compartment.
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Reviewed in the United States on August 15, 2024
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Chris TeKippe
Los Angeles, US
★★★★★ 5
Works exactly as stated with a dual axel trailer
Color: Yellow, Size: 5.5" Lift
I purchased this on a hope, I had a trip planned to pull a school trailer 2600 miles round trip and had to use my pickup truck jack if I had a tire issue. I didn't like my odds and bought this ramp hoping it would make things simpler. My second day into driving and I had my first tire blow out. The ramp workers perfectly and I had the new tire on the trailer in 15 minutes. Later in the day, I caught a second tire on the trailer down to threads and used the ramp again to change out tires at a truck stop. I analyzed all the "whys" as to what made the tires blow and fixed it to make the rest of my trip safe and trouble free but this ramp made things quick and easy when i needed it. I'd totally recommend this product and I'm planning to purchase another and leave it with the school trailers for future use. Keep in mind you need at least a dual axel trailer for this to work and have a spare tire to swap to.
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