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Description
IL-17F Protein, RatProduct Specification Species Rat Synonyms Interleukin 17F, IL 17F Accession Q5BJ95 Amino Acid Sequence Arg29 Ala161 Expression System HEK293 Molecular Weight 18 24 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Rat |
| Synonyms | Interleukin-17F, IL-17F |
| Accession | Q5BJ95 |
| Amino Acid Sequence | Arg29-Ala161 |
| Expression System | HEK293 |
| Molecular Weight | 18-24 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Signal Transduct Target Ther. 2023 Oct 11;8(1):402. |
Background
Interleukin-17F (IL-17F) is a pro-inflammatory cytokine belonging to the IL-17 cytokine family. In rats, IL-17F is predominantly expressed by activated T-helper 17 (Th17) cells, CD8+ T cells, γδ T cells, and innate immune cells such as neutrophils and macrophages. The rat IL-17F protein shares about 55% sequence homology with IL-17A and can form homodimers or heterodimers with IL-17A, both of which exert biological effects by binding to the IL-17 receptor complex (IL-17RA and IL-17RC).
IL-17F is involved in host defense against bacterial and fungal infections and plays a significant role in the pathogenesis of autoimmune and inflammatory diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. In rat models, IL-17F has been shown to induce neutrophil recruitment, promote the release of pro-inflammatory cytokines and chemokines, and contribute to tissue inflammation and bone destruction.
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