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Description
CD98/SLC3A2 His Tag Protein, HumanProduct Specification Species Human Synonyms CD98, SLC3A2, 4F2, 4F2HC, 4T2HC, CD98HC, MDU1, NACAE Accession P08195 Amino Acid Sequence Arg206 Ala630, with N terminal 8*His
Product Specification
| Species | Human |
| Synonyms | CD98, SLC3A2, 4F2, 4F2HC, 4T2HC, CD98HC, MDU1, NACAE |
| Accession | P08195 |
| Amino Acid Sequence | Arg206-Ala630, with N-terminal 8*His HHHHHHHHGGGSRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA |
| Expression System | HEK293 |
| Molecular Weight | 55-72kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Fenczik C A. et al. (2001) Distinct domains of CD98hc regulateintegrins and amino acid transport. J Biol Chem. 276(12): 8746-52. 2、Verrey F. et al. (2004) CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch. 447(5): 532-542. 3、Meier C. et al. (2002) Activation of system L heterodimeric amino acid exchangers by intracellular substrates. EMBO J. 21(4): 580-589. |
Background
CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2 constitutes the heavy chain part of HATs and is an essential structure for transporting amino acids, while the light chain part (i.e. LATs) contains catalytic groups that catalyze the transport of amino acids. HATs transport almost all essential amino acids, and different HATs have specific transport functions for different amino acids. Among them, SLC3A2/LAT1 is mainly responsible for transporting most neutral amino acids (such as leucine, isoleucine, methionine, etc.) and aromatic amino acids, while SLC3A2/LAT2 can mediate the transport of all neutral amino acids, and is also the transporter of thyroid hormone. SLC3A2 is widely expressed in a variety of rapidly proliferating cells, and is involved in regulating a variety of important cell activities, playing an important role in cell growth and embryonic development. SLC3A2 has dual functions of regulating amino acid transport and integrin downstream signaling pathways, and studies have found that the extracellular region and the cytoplasmic region of SLC3A2 are two relatively independent functional regions, in which the extracellular region is closely related to amino acid transport, while the cytoplasmic region and transmembrane region are necessary for the interaction with integrins.
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4.5 ★★★★★
Based on 516 reviews
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Product Reviews
★★★★★ 3
Slightly repetitive but I did love some things
Format: Kindle
I love this type of story. And omegaverse is one of my all time favorite genres. But there are a few things that pulled me out of my enjoyment while I was reading. It was repetitive at times as well as struggled with telling not showing. So we didn’t always feel like we were experiencing things with the main character. There were also some plot holes but they may still be answered in part 2.
Now this isn’t to be said I didn’t enjoy parts of the story. I loved the almost instant love between Mila and Oliver. And how he started changing around her.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2024
★★★★★ 5
delightful read
Format: Kindle
What a delightful read. The characters are awesome, the plot was so good, I loved it. I was intrigued and it kept me wanting more. Told in multiple pov, the book sucks you in and doesn’t let go. I cannot wait to read the next book.
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Reviewed in the United States on January 30, 2025
★★★★★ 4
not bad
Format: Kindle
I loved the plot of this book. The characters just didn’t have a lot of depth. The connections and “love” just weren’t communicated very well in the writing. The author didn’t write the sweet psycho trope very well at all either. Lachlan was just a mess of a character.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 17, 2023
★★★★★ 5
A Beta Worth Rooting For
Format: Kindle
In Spare, Violet Fox flips the omegaverse on its head, giving us a Beta heroine determined to make her mark. Joining the Beta Trials to support her sick father, she's thrown into a pack that doesn't want her, especially the possessive Alphas.
But here's the twist: their sweet Omega turns out to be her scent match. Cue the angst, forbidden tension, and a slow-burn romance that will make your heart ache in the best way.
Violet Fox delivers an emotional, refreshing take on the genre, proving Betas aren't "spares." They're stars.
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Reviewed in the United States on January 10, 2025
★★★★★ 5
Beta, Alpha, Omega oh my!
Format: Kindle
Omegas are precious and given to Alphas & their packs... but the Betas want in too. To this end, the Beta government is rolling out its trial of assigning a Beta to each Alpha-Omega pack. But forcing a Beta into a pack where they are not wanted will not end well... Of course, no one expected the Omega to fall for the assigned Beta. Great read and cliffhanger
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 15, 2025
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