Axl His Tag Protein, Human
SKU: 77676299576

Axl His Tag Protein, Human

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Description

Axl His Tag Protein, HumanProduct Specification Species Human Synonyms Axl, UFO, Tyro7, JTK11, ARK Accession P30530 1 Amino Acid Sequence Ala26 Trp451, with C terminal His Expression System HEK293 Molecular Weight 60 78kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Human
Synonyms Axl, UFO, Tyro7, JTK11, ARK
Accession P30530-1
Amino Acid Sequence Ala26-Trp451, with C-terminal His
Expression System HEK293
Molecular Weight

60-78kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Weinger J G. et al. (2011) Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis. J Neuroinflammation. 8: 49.

2、Linger R M. et al. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opin Ther Targets. 14(10): 1073-1090.

3、Cavet M E. et al. (2010) Gas6-Axl pathway: the role of redox-dependent association of Axl with nonmuscle myosin IIB. Hypertension. 56(1): 105-111.

4、Rankin E B. et al. (2010) AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 70(19): 7570-7579.

Background

AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. Mature human Axl consists of a 426 aa extracellular domain (ECD) that contains two Ig-like domains and two fibronectin type III domains, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain that includes the tyrosine kinase domain. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multiple cell types. Axl functions in dampening the immune response, regulating cytokine secretion, clearing apoptotic cells and debris, and maintaining cell survival. Axl is upregulated in various disease states, such as in the cuprizone toxicity-induced model of demyelination and in multiple sclerosis (MS) lesions, suggesting that it plays a role in disease pathogenesis. The receptor tyrosine kinase (RTK) AXL has been associated with poor prognosis in numerous malignancies and the emergence of therapy resistance. Upon binding to its ligand GAS6, AXL regulates cell signaling cascades and cellular communication between various components of the tumor microenvironment, including cancer cells, endothelial cells, and immune cells. Converging evidence points to AXL as an attractive molecular target to overcome therapy resistance and immunosuppression, supported by the potential of AXL inhibitors to improve ICI efficacy. Axl contributes to cell survival, migration, invasion, metastasis and chemosensitivity justify further investigation of Axl as novel therapeutic targets in cancer. The soluble AXL receptor as a therapeutic candidate agent for treatment of metastatic ovarian cancer.

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SKU: 77676299576

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JL
Omaha, US
★★★★★ 5
Nice shirt at a good price
Size: Small, Color: Indigo
Nice shirt, fits well and is a nice color and button layout. It was a good deal.
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Reviewed in the United States on April 7, 2026
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Mark benn
Battle Creek, US
★★★★★ 5
Love it
Size: Large, Color: Indigo
Good quality
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Reviewed in the United States on May 20, 2026
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Jon J. Sanders
Draper, US
★★★★★ 3
Its OK but wrinkles easily.
Size: X-Large, Color: Light Khaki Brown
Decent shirt and fits well, but wrinkle city! I could barely iron them out after washing.
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Reviewed in the United States on May 25, 2026
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Jacob
New York, US
★★★★★ 5
Good shirt.
Size: Large Tall, Color: Green Camo Print
New favorite shirt. Definitely a LT. cheapest big and tall button down i could find and i love it.
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Reviewed in the United States on April 10, 2026
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Dan
Carnegie, US
★★★★★ 4
Nice shirt but size up one to two sizes.
Size: Large, Color: Clay
I love this shirt. it is good quality. I got the clay colored one. I really like it. They do run small. I normally wear a medium. So I got a large. It fits pretty well. It is a tad bit tight, but I am losing weight(145LBS) So far. So it should fit fine in a few weeks. I am 5,2 135Lbs. I probably should have gotten the XL.
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Reviewed in the United States on May 17, 2026

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